Impaired reflex control of intestinal gas transit in patients with abdominal bloating

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INTESTINAL MOTILITY Impaired reflex control of intestinal gas transit in patients with abdominal bloating

Background: Patients with abdominal bloating and distension exhibit impaired transit of intestinal gas which may lead to excessive gas retention and symptoms. Furthermore, we have previously shown that intestinal gas transit is normally accelerated by rectal distension. We hypothesise that in patients with functional bloating this modulatory mechanism fails and impairs gas transit. Methods: In ...

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Impaired reflex control of intestinal gas transit in patients with abdominal bloating.

BACKGROUND Patients with abdominal bloating and distension exhibit impaired transit of intestinal gas which may lead to excessive gas retention and symptoms. Furthermore, we have previously shown that intestinal gas transit is normally accelerated by rectal distension. We hypothesise that in patients with functional bloating this modulatory mechanism fails and impairs gas transit. METHODS In ...

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REFLEX CONTROL OF INTESTINAL GAS DYNAMICS AND TOLERANCE IN HUMANS Running title: reflex control of intestinal gas dynamics

Intestinal transit of gas is normally adapted to the luminal gas load, but in some patients impaired transit may lead to gas retention and symptoms. We hypothesized that intestinal gas transit is regulated by reflex mechanisms released by segmental distension at various gut levels. In 24 healthy subjects we measured gas evacuation and perception of jejunal gas infusion (12 ml/min) during simult...

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Molecular characterization of the intestinal microbiota in patients with and without abdominal bloating.

Recent studies have demonstrated differences in the intestinal microbiota between patients with irritable bowel syndrome (IBS) and healthy controls (HC), suggesting a role for the intestinal microbiota in the pathogenesis of IBS. Alterations in the microbiota have also been implicated in the pathogenesis of abdominal bloating, a commonly reported symptom in IBS. We investigated the relationship...

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ژورنال

عنوان ژورنال: Gut

سال: 2005

ISSN: 0017-5749

DOI: 10.1136/gut.2003.038158